Impact of different treatment plans on EQD2 for intracavitary brachytherapy of cervical cancer

Abstract Background Cancer is one of the leading causes death worldwide. According to GLOBOCAN estimates, there were 341,831 deaths from cervical cancer in 185 countries 2020. The aim this study was compare equieffective dose (EQD 2 ) at Gy per fraction by using volume histograms (DVHs) derived external beam radiotherapy (EBRT) and high-dose rate brachytherapy (HDR-BRT) treatment plans used radiotherapy. Methods Fifteen patients with stage IIB-IIIB included retrospective study. Treatment three-dimensional conformal (3D-CRT) or intensity-modulated (IMRT) planned for all 28 fractions, a total 50.4 be delivered whole pelvic region. After EBRT, manual optimization (MO) inverse (IO) HDR-BRT created 4 fractions Gy. obtained grouped as IMRT + IO, MO, 3DCRT MO calculating EQD s among these plans. D 90 , 95 98 values compared CTV HR . In addition, ​for critical organs risk (OARs) such rectum, bladder, small intestine, sigmoid volumes cm 3 1 0.1 respectively. Results There no significant difference between groups terms IR values; However, ( p = 0.000) CTVHR D98 ​were found better IO technique. technique provided protection OARs other techniques. Conclusions Considering parameters sigmoid, combination option significantly superior EQD2 calculations